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Antabuse and alcohol

Result of checker of drug Antabuse interaction with alcohol. Whether they can be taken together or this combination is not allowed.

Check result:
Antabuse <> Alcohol
Relevance: 01.01.2021

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug interaction with alcohol.

Consumer:

You should not drink alcoholic beverages or use medicines that contain ethanol during treatment with disulfiram. This can cause flushing, nausea and vomiting, blurred vision, shortness of breath, rapid heart beat, and low blood pressure. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Consumption of ethanol during treatment with disulfiram may cause flushing, nausea, blurred vision, dyspnea, tachypnea, tachycardia, and hypotension. Death has been reported. The mechanism is probably related to inhibition of aldehyde dehydrogenase, the enzyme responsible for the oxidation of acetaldehyde to acetyl CoA. Accumulation of acetaldehyde probably results.

MANAGEMENT: Ethanol should be avoided in patients receiving disulfiram.

References:
  • Stoll D, King LE "Disulfiram-alcohol skin reaction to beer-containing shampoo." JAMA 244 (1980): 2045
  • van Ieperen L "Sudden death during disulfiram-ethanol reaction." S Afr Med J 66 (1984): 165
  • Jones RO "Death following the ingestion of alcohol in an antabuse treated patient." Can Med Assoc J 60 (1949): 609-12
Antabuse

Generic Name: disulfiram

Brand Name: Antabuse

Synonyms: n.a.

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