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Isoniazid and rifampin and alcohol

Result of checker of drug Isoniazid and rifampin interaction with alcohol. Whether they can be taken together or this combination is not allowed.

Check result:

Isoniazid and rifampin <> Alcohol

Relevance: 01.01.2021

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug interaction with alcohol.

Consumer:

Using isoniazid together with rifAMPin can cause serious side effects that may affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: The risk of hepatotoxicity is greater when rifampin and isoniazid are given concomitantly than when either drug is given alone. Rifampin appears to alter the metabolism of isoniazid and increase the amount of toxic metabolites. Theoretically, a similar reaction may occur with rifabutin and isoniazid. Patients who are elderly, have hepatic impairment, are slow acetylators of isoniazid, drink alcohol daily, are female, or are taking other strong CYP450-inducing agents may be at greater risk of hepatotoxicity.

MANAGEMENT: Close monthly monitoring for clinical or laboratory evidence of altered hepatic function is recommended. Patients should be advised to promptly report early symptoms of hepatitis such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. Discontinuation of either or both drugs may be necessary.

References:

Askgaard DS, Wilcke T, Dossing M "Hepatotoxicity caused by the combined action of isoniazid and rifampicin." Thorax 50 (1995): 213-4
"Product Information. Mycobutin (rifabutin)." Pharmacia and Upjohn, Kalamazoo, MI.
Kumar A, Misra PK, Mehotra R, et al "Hepatotoxicity of rifampin and isoniazid." Am Rev Respir Dis 143 (1991): 1350-2
Abadie-Kemmerly S, Pankey GA, Dalvisio JR "Failure of ketoconazole treatment of blastomyces dermatidis due to interaction of isoniazid and rifampin." Ann Intern Med 109 (1988): 844-5
Steele MA, Burk RF, Des Prez RM "Toxic hepatitis with isoniazid and rifampin." Chest 99 (1991): 465-71
Yamamoto T, Suou T, Hirayama C "Elevated serum aminotransferase induced by isoniazid in relation to isoniazid acetylator phenotype." Hepatology 6 (1986): 295-8
"Product Information. INH (isoniazid)." Ciba Pharmaceuticals, Summit, NJ.
O'Brien RJ, Long MW, Cross FS, et al "Hepatotoxicity from isoniazid and rifampin among children treated for tuberculosis." Pediatrics 72 (1983): 491-9
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
Sarma G, Immanuel C, Kailasam S, Narayana AS, Venkatesan P "Rifampin-induced release of hydrazine from isoniazid." Am Rev Respir Dis 133 (1986): 1072-5
Acocella G, Bonollo L, Garimoldi M, et al "Kinetics of rifampicin and isoniazid administered alone and in combination to normal subjects and patients with liver disease." Gut 13 (1972): 47-53
"Product Information. Rifadin (rifampin)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Isoniazid and rifampin

Generic Name: isoniazid / rifampin

Brand Name: IsonaRif, Rifamate

Synonyms: n.a.

What is Isoniazid and rifampin?

Another drug Delete

Isoniazid and rifampin <> Alcohol

Relevance: 01.01.2021

Consumer:

Isoniazid may cause liver problems, and taking it with alcohol can increase the risk. You should avoid or limit the use of alcohol while being treated with isoniazid. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Alcoholic patients have been shown to have a higher incidence of isoniazid-induced hepatotoxicity. The mechanism has not been established.

MANAGEMENT: Patients should be counseled to avoid the combination of alcohol and isoniazid and clinicians should be aware of the risk for increased hepatotoxicity in these patients.

References: